Do antidepressants increase the risk of suicide? There are certainly people out there who are very vocal in insisting that they do. However, as is so often the case, the loudmouths don't tend to be especially well informed. The FDA black box warning Since 2004, the U.S. Food and Drug Administration (FDA) has required a… Continue reading Antidepressants and Suicide Risk
Mediamodifier on Pixabay I recently watched the documentary Letters From Generation Rx, which looked at instances of people experiencing significant side effects while on psychiatric medication, including people who took the lives of either themselves or others while on psychiatric meds. One man featured in the film was a Canadian Member of Parliament whose teenage… Continue reading Generation Rx – Weighing Medication Risks & Benefits
Wouldn't it be nice if the treatment of depression was simple? Unfortunately, there's nothing simple about depression treatment in the real world. Treatment-resistant depression (TRD) refers to illness that hasn't respond to trials of adequate duration and dosage of at least two antidepressants. The STAR*D research study found that only about 1/3 of people get… Continue reading Treatment-Resistant Depression: When What’s Supposed to Work Doesn’t
I love Canada, but sometimes we're a little behind. Drug approval by Health Canada is slower than in the US, and fewer clinical trials are done here. I'd be really interested in trying out ketamine, but it doesn't have Health Canada approval for use in depression, there are no clinical trials in my neck of… Continue reading Ketamine for Treatment-Resistant Depression
geralt on Pixabay The Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial studied 2876 people with major depressive disorder to evaluate their response to depression treatment in a real-world setting. Unlike the randomized controlled trials that are often used to evaluate a drug's efficacy, there were few exclusion criteria, the patient and their physician knew… Continue reading What the STAR*D Study Means for Depression Treatment
Do antidepressants work? There's a lot of stigma around psychiatric medications, and plenty of people would argue that no, antidepressants don't work. There are also people, that argue that medication is life-saving. Those are personal experiences, but what does the research have to say? A recent paper published in the Lancet, and reported on in… Continue reading Do Antidepressants Work?: A New Meta-Analysis
I have always been a big fan of the documentary program The Passionate Eye on CBC, Canada's public broadcaster. Until now. On January 6, 2018, they aired "A Prescription for Murder?", which was originally shown on the BBC. The program focused on James Holmes, the young man who shot and killed 12 people and injured 70… Continue reading A Prescription For Murder?
Despite what the title might suggest, this post isn't about me being self-critical. I've been struggling for months with cognitive symptoms of depression, and on a daily basis I notice that it impairs my overall functioning. But it's not something I've ever had much of an objective sense of, until I tried the THINC-it test.… Continue reading I’m Actually Getting Stupider: The THINC-it Test in Depression
This post breaks down what I take to manage my depression - it's a long list, but it's a tough illness.
A look at how antidepressants work