scale with uneven balance

Dead if you do, dead if you don’t? Weighing the risks & benefits of medications

I recently watched the documentary Letters From Generation Rx on Amazon Prime, which looked at instances of people experiencing significant side effects while on psychiatric medication, including people who took the lives of either themselves or others while on psychiatric meds. One man featured in the film was a Canadian Member of Parliament whose teenage … Continue reading Dead if you do, dead if you don’t? Weighing the risks & benefits of medications

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Treatment resistant depression: When what’s supposed to work doesn’t

Wouldn't it be nice if the treatment of depression was simple?  Unfortunately, there's nothing simple about depression treatment in the real world.  Treatment-resistant depression (TRD) refers to illness that hasn't respond to trials of adequate duration and dosage of at least two antidepressants.  The STAR*D research study found that only about 1/3 of people get … Continue reading Treatment resistant depression: When what’s supposed to work doesn’t

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brain shining like a star

What the STAR*D study means for depression treatment

The Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial studied 2876 people with major depressive disorder to evaluate their response to depression treatment in a real-world setting.  Unlike the randomized controlled trials that are often used to evaluate a drug's efficacy, there were few exclusion criteria, the patient and their physician knew which drug they … Continue reading What the STAR*D study means for depression treatment

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pills and capsules

Do antidepressants work? What a new meta-analysis says.

A recent paper published in the Lancet looked at how effective antidepressants are, and this has been reported on in the media.  Since media outlets don't necessarily have strong research literacy, let's take a look at what the paper itself has to say.  My earlier post on research literacy explains some of the terms I'll be using … Continue reading Do antidepressants work? What a new meta-analysis says.

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THINC-it test results for cognition in depression

I am actually getting stupider: The THINC-it test in depression

Despite what the title might suggest, this post isn't about me being self-critical.  I have been struggling for months with cognitive symptoms of depression, and on a daily basis I notice that it impairs my functioning.  But it's not something I've ever had much of an objective sense of. Measuring cognitive function in depression Until … Continue reading I am actually getting stupider: The THINC-it test in depression

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