Mental health

Naltrexone – An Opioid Blocker That Gets Around

List of different therapeutic uses for naltrexone

Naltrexone (brand names include Vivitrol and ReVia) blocks opioid receptors just like Narcan (naloxone), which is used to treat opioid overdoses.  Both drugs prevent any opioids in the vicinity From being able to latch onto opioid receptors and do their opioid thing.  While Narcan and fast- and short-acting, naloxone works more slowly and is longer-acting.  It’s available as a once daily pill or as a monthly injection.  It’s FDA approved for use in addictions, but it’s also been used off-label in quite a wide range of other conditions.


Not surprisingly, naltrexone can be used to treat opioid addiction.  However, it really gets around, and it can be used in a number of other conditions, suggesting that our body’s natural opioid system is probably busier than we might think.

Naltrexone can be used for alcoholism, even though alcohol doesn’t act at opioid receptors.  It’s also been used for dextromethorphan (the DM in cough syrup) dependence.

Mental health-related uses

There have been a few case studies published of naltrexone being helpful for compulsive sexual behaviour and kleptomania.

A number of studies have found positive results in PTSD with co-occurring alcohol use disorder.  There is also some indication that naltrexone may have some effectiveness as an add-on treatment for PTSD without alcoholism.

Naltrexone has been used for dissociative disorders, including dissociative identity disorder.  It’s also shown some effectiveness for dissociation and self-injury in borderline personality disorder.  The exact link to the opioid system is unclear.

A small pilot study showed positive results adding naltrexone on to breakthrough symptoms of major depressive disorder for people who were already on a particular set of medications.  I didn’t come across any follow-up studies.

Pain disorders

There’s been some research to suggest that at lower than standard doses, naltrexone can have an anti-inflammatory effect that targets a number of different inflammatory and immune mediators in the body as well as microglial cells in the brain.  Calming down microglia could, at least theoretically, help to reduce neuropathic (nerve) pain.

Some studies have shown that naltrexone can decrease pain in fibromyalgia.  Fibromyalgia is thought to have a neuro-immune component, which may explain how naltrexone is helpful.

In multiple sclerosis, there is some evidence that naltrexone can improve energy and quality of life,

There are some early indications of efficacy have been seen with use of naltrexone for Crohn’s disease, diabetic neuropathy, and chronic lower back pain, but there isn’t enough research yet to give a clear indication as to whether it actually works for these conditions.


The combination of naltrexone and the antidepressant bupropion (brand names Contrave, Mysimba) is used for obesity, with each component decreasing appetite by a different mechanism.

Why the diverse uses?

While there are quite a few drugs that do multiple different things, naltrexone is interesting in terms of how disconnected some of these uses seem at first glance.  Then again, there are also connections.

Compulsive behaviours and addictions seem like they would logically share elements of underlying mechanisms.  If you consider that the body’s natural opioid system responds to pain, and dissociation may be a defense strategy in certain types of painful situations, the link to naltrexone seems plausible.

Then there’s the anti-inflammatory element.  There seems to be a steadily growing body of evidence that inflammation places a fundamental role in a wide variety of conditions.  Science really needs to find a way for us to flick a switch to tell our bodies’ inflammatory systems to calm the f*** down.

In the meantime, we’ve got naltrexone.


Thanks to my friends at We DID It for suggesting this topic.



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18 thoughts on “Naltrexone – An Opioid Blocker That Gets Around”

  1. Wow! It sounds like a wonder drug. I hope more research is done, and even that the pharmaceutical companies come up with components of it that can help different issues more specifically. That would rock! I love this age we live in of new discoveries and treatments. Great blog post!

  2. I used low dose naltrexone (LDN) for MS for many years, until I had chemo to reset my immune system instead. It was hard to give up LDN though, and you can’t use the two together so I had to make a hard choice!

      1. It is but I was worried somehow LDN was keeping me psychologically upbeat. Haven’t come crashing down yet and it’s been a few years now without it, so looks like I escaped that bullet. Plus, LDN improved my MS but chemo improved it even further, so it’s been worth it so far. It felt like quite a gamble though!

  3. Yay, you said we are your friends! Great to see that in writing (wink). Thanks for researching this topic!

    This is a truly amazing drug. We like how you connected all these compulsive behaviors. That and inflammation. We hope someone does a meta-study of naltrexone benefits to figure out more of how the brain works.

    Were you surprised just how many conditions this stuff is treating? We are blown away!

  4. Great and really informative post about naltrexone. My shrink already suggested me, but I’m collecting some more info. Thanks for it 🙂

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