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Getting Botox for Treatment-Resistant Depression

Botox for depression: A surprising option for treatment-resistant depression

Would you have guessed that Botox could help with treatment-resistant depression? Probably not, but read on to find out about my experience with it.

I’m not a cosmetic procedures kind of gal, and Botox (botulinum toxin) was never on my wish list. Power to others if that’s what works for them, but given that I can’t even be bothered putting on makeup most of the time, all things physical appearance-related don’t rank very high on my priority list.

The research on Botox for depression

But that’s not why I’ve just gotten Botox. To keep my knowledge base up to date in the field of psychiatry I try to watch webinars on a somewhat regular basis. The other day I was watching a webinar on novel treatments for depression, and one of the things mentioned was Botox. There have been a few small research studies, listed at the end of this post, that found that injecting Botox into the frown line areas on the forehead actually led to an improvement in depressive symptoms, even in people with treatment-resistant illness. The thinking behind it is that not only does facial musculature express mood states, but it gives feedback that in turn regulates mood states. By preventing frowning, Botox may disrupt that harmful feedback loop.

Will it work? Who knows. At this point, I’m willing to try just about anything. I’m doing this with my naturopath, who does cosmetic procedures as part of her practice. I trust her, and she thinks it’s a good idea, so what the heck, might as well give it a go. Fingers crossed!

A Botox update 5 weeks later

Around 5 weeks ago, I got my first Botox injections. I then got round #2 a couple of weeks later, for a total dose of 29 units, which was the amount used in the relevant research studies.

For anyone who’s curious, botulinum toxin comes from the Clostridium botulinum bacteria and acts at the neuromuscular junction to cause muscle paralysis. Besides cosmetic use, it’s used for a number of different muscular disorders, hyperhidrosis (excessive sweating), and in the prevention of migraines. Effects are expected to last 3-4 months, although in the studies for depression the beneficial effect was found to last even longer.

Numb but not numb

It takes about 2 days to start noticing the effects and 2 weeks to get the full effect. I would describe the feeling as numb but not numb. It feels numb much the same way as if your mouth was numb after going to the dentist and you couldn’t move the area. When I try to move the muscles in my forehead, I get that same sort of numb feeling.

It’s not numb to sensory input, though, so I still feel touch, pressure, temperature, and other sensations.

What I’ve really noticed is how often I was frowning before. Since I get that numb feeling when I try to move my forehead, I notice when I’m trying to frown. And it happens often, far more often than I would have guessed.

In terms of outward appearance, when I try to frown, there are some little crinkles visible above the outer half of each eyebrow, but that’s it. When I raise my eyebrows in a surprised sort of expression, there’s limited movement, but one eyebrow raises more than the other one, a fun little quirk that my naturopathic doctors said she could fix but I actually kind of like.

Does it work?

So, is the Botox helping with my mood?  I’ll say a cautious maybe. I’m still having bad days and I have no resilience when it comes to situational stressors, but looking at my mood tracking app, there has been a bit of an improvement over the last couple of weeks. It’s always hard to know what’s causing what, and there are probably other things that are helping, like the approach of spring and some more positive interpersonal interactions.

I’ll probably never really know for sure what effect if any the Botox is having, but I do like the idea that it’s getting in the way of all the frowning I was apparently doing before. And at this point, I’m willing to do pretty much anything, even if it’s only having a small impact.


book cover: Managing the Depression Puzzle, 2nd Edition, by Ashley L. Peterson

Managing the Depression Puzzle takes a holistic look at the different potential pieces that might fit into your unique depression puzzle.

It’s available on Amazon and Google Play.

32 thoughts on “Getting Botox for Treatment-Resistant Depression”

  1. Awesome! It makes sense if you ask me. Also our physical appearance helps us to feel better internally without being egotistical, I’ve found this to be true.

    1. Apparently results can be seen by 6 weeks after a single treatment, and can last 24 weeks (which is interesting, because the cosmetic effects don’t last that long).

  2. Great information. I’ve had Botox several times and can’t say my depression improved. That doesn’t Botox is not an answer for many. I’m going again in two weeks, I’ll pay more attention to any improvement of depression. Good luck. It doesn’t hurt, they use very small needles.

  3. Hmm, I have never heard it used for depression except if people felt it would improve their looks, although I have heard that many were not happy with it and have turned away from it. Let us know if it has results for you, if you get it. Best wishes–

  4. I had never heard of this before, but the logic makes sense. I’m glad you’ve got a trusted professional to guide you, that certainly helps the decision-making process. I hope you’ll keep us in the loop about how you think it works.

  5. I truly hope that it does some good for you. Placebo or not.
    I have not seen this research, but it remind me of research I am aware of – mainly, force yourself to smile. If you do it enough times and for a long enough time, your brain will start to believe you are actually happy and will combat your sadness. So this is somewhat in line with what you’re saying.
    Again, I hope it helps you, keep us posted, but I am very skeptical from a medical perspective.

    1. I’ve heard about the smiling thing, and I’ve found that trying to make myself smile when I’m feeling crappy just annoys me because the fakeness of it reminds me of just how bad I’m feeling. Anyway, we’ll see how things go,.

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